Monday, September 15, 2014

Persistence Paying Off?

in this instance, it may indeed, and all of us will be the better for it.  MIT Technology Review has a terrific article about the trials and tribulations of a group of medical researchers who thought they had a made a valuable discovery of a genetic-level medical treatment. Indeed, the primary researchers involved won a Nobel prize for their efforts. In fact,
Inspired by the discovery, another group of researchers—including the former thesis supervisor of one of the Nobel laureates—founded Alnylam in Cambridge, Massachusetts, in 2002. Their goal: fight diseases like FAP by using RNAi to eliminate bad proteins (see “The Prize of RNAi” and “Prescription RNA”). Never mind that no one knew how to make a drug that could trigger RNAi. In fact, that challenge would bedevil the researchers for the better part of a decade. Along the way, the company lost the support of major drug companies that had signed on in a first wave of enthusiasm. At one point the idea of RNAi therapy was on the verge of being discredited.
Now, however, things are looking bright and exciting again.  Read about the discovery, its large range of application, and the behind-the-scenes business elements involved by clicking here.  Fascinating article and good example of persistence paying off (hopefully!). [ht: instapundit]